凯恩继续追查手提箱核弹一案，但是他感觉中央情报局内部有人似乎刻意阻止他查案，凯恩感觉时间紧迫，很快他与老友组建了一支新的特工小分队，由他一手训练，指挥。终于他们在手提箱到达幕后买家手里之前阻击了这场交易。凯恩知道真正的死亡降临了，前所未有的接近……

American operative Court Gentry, also known as the Gray Man, races against time and teams of government assassins in an effort to save his family.